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Re-evaluation of β-cyclodextrin (E 459) as a food additive


Published on: Wed, 07 Dec 2016 13:45:15 +0100

The EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific opinion re-evaluating the safety of β-cyclodextrin (E 459) as a food additive. β-Cyclodextrin is a non-reducing cyclic oligosaccharide consisting of seven α-1,4-linked d-glucopyranosyl units. The Scientific Committee on Food (SCF) allocated an acceptable daily intake (ADI) of 5 mg/kg body weight (bw) per day to β-cyclodextrin (E 459) in 1996. β-Cyclodextrin is poorly absorbed following oral administration in animals and humans. It is hydrolysed to maltose and glucose by the gut microflora and endogenous amylases in the colon; consequently, β-cyclodextrin levels in tissues and serum are low (brand-loyal scenario (considered the most relevant scenario) in all population groups except for infants at the mean and in all population groups at the 95th percentile.

© European Food Safety Authority, 2015

Re-evaluation of β-cyclodextrin (E 459) as a food additive

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