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Safety and efficacy of ENZY CARBOPLUS® (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species

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Published on: Thu, 21 Dec 2017 00:00:00 +0100

ENZY CARBOPLUS® is an additive available in liquid and solid forms that contains endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase which are produced by two genetically modified strains of Komagataella pastoris. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the production strains are safe and the genetic modifications raise no safety concerns. The Panel also concluded that the additive is safe for the target species at the recommended dosages and that its use as a feed additive raises no concern for consumers. The additive in either form is not a skin or eye irritant nor a dermal sensitiser; however, it is considered as a potential respiratory sensitiser. The production strains and their recombinant DNA were not detectable in the additive; moreover, the active substances of the additive will be degraded/inactivated during passage through the digestive tract of animals or in the environment, consequently, the Panel concluded that the additive poses no concerns to the environment. The Panel concluded that the additive has a potential to be efficacious as a zootechnical additive in chickens for fattening at 4,000 LXU and 375 LGU per kg feed, in turkeys for fattening at 1,400 LXU and 120 LGU per kg feed, and in weaned piglets at 700 LXU and 60 LGU per kg feed. The Panel extended these conclusions to chickens reared for laying and turkeys reared for breeding at the corresponding doses. Since the mode of action of xylanase and glucanase can be reasonably assumed to be the same within avian or within porcine species, the Panel extrapolated the conclusions on the efficacy to all avian species up to the point of lay and to all porcine species. Owing to the lack of data, no conclusions could be drawn on the efficacy of the additive in laying hens.

© European Food Safety Authority, 2015

Safety and efficacy of ENZY CARBOPLUS® (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species


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